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Description

Collectively, these properties position polyphenols and flavonoids as key therapeutic agents for oxidative stress-related skin conditions like vitiligo and melanoma, emphasizing the need for further clinical validation 148

Sugiura K, Pendola FL, Eppig JJ

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In cells expressing eNOS with low biopterin levels, DHFR inhibition or knockdown further diminished the BH4:BH2 ratio and exacerbated eNOS uncoupling [60,61]